The role of interleukin 6 in the pathogenesis of hyponatremia associated with Guillain-Barré syndrome.

Nefrologia 2012;32(1):114-32 Furthermore, Mastorakos et al. reported that plasma antidiuretic hormone levels were elevated after IL-6 injection in cancer patients, suggesting that IL-6 activated the magnocellular ADH-secreting neurons and that it might be involved in SIADH. Activation of the subfornical organ and the organum vasculosum of the lamina terminalis by IL-6 could eventually lead to thirst and increased vasopressin secretion by neurons from the supraoptic nucleus and paraventricular nucleus. The combination of antidiuresis and increased water intake may result in hyponatremia.